A prevailing theory is that imbalances of excitatory and inhibitory (E/I) signals in the brain underlie information processing defects in ASD. This theory relates to the observation that many individuals with autism experience seizures and display ongoing ‘sharp spike’ activity during wake stage and even more frequently in sleeps. E/I balance is regarded critical for the shaping of sensory processing networks during early postnatal stages as well as to maintain sensory functions through supporting roles such as network synchronization, noise filtering and sensory binding. Surprisingly, it has taken until the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to formally acknowledge sensory difficulties as a core diagnostic feature of ASD and mechanistic understanding of sensory processing alterations in ASD is limited. In this panel, we present studies of two large ongoing sensory driven translational ASD research projects in the Netherlands, the Sensory Processing Program in Utrecht/Amsterdam and the BECAUSE project in Amsterdam. We will present novel neurophysiology approaches and techniques to elucidate associations between E/I balance and sensory processing components that may support rational treatment decisions in ASD with and without epilepsy comorbidity.