Objectives: The following study aims to compare the DTI findings in SLOS with TD controls. Outcome measures include mFA, MD, and volume for 40 atlas-based ROI previously described in studies of individuals with autism and Rett syndrome. A secondary aim is to compare the DTI findings in SLOS with those reported in autism and Rett syndrome.
Methods: Ten children (mean= 10.1 years +/-5.5) with SLOS, and 27 TD controls (mean=9.7 years +/-7.5) received 3T MRI scans. Statistical analyses applied student’s T-test. SLOS children underwent ASD testing with ADI-R and ADOS by expert clinicians who emitted a clinical judgment using DSM-IV criteria.
Results: Individuals with SLOS showed higher mFA, decreased volume, and decreased MD compared to controls for the majority of ROI studied (30/40, 75%). These results contrast with the pattern of microstructural findings in children with autism and Rett syndrome. Pending analysis within SLOS group will compare microstructural diffusion characteristics between autistic and non-autistic SLOS children.
Conclusions: The pattern of DTI findings in SLOS differ from those reported in autism, Rett syndrome and controls. These findings suggest that while autistic symptoms are present in these three neurodevelopmental disorders, a unique microstructural substrate in SLOS may be underlying the autistic behaviors described in the phenotype. Further studies are required to reveal the neurobiologic causes of autistic behavior in SLOS.
See more of: Brain Imaging
See more of: Brain Structure & Function