27199
Symptom Severity Trajectories from Infancy to Childhood in Siblings at Risk for Autism Spectrum Disorder: Social Affect and Restricted and Repetitive Behaviors.

Friday, May 11, 2018: 11:30 AM-1:30 PM
Hall Grote Zaal (de Doelen ICC Rotterdam)
M. Franchini1, E. Duku2, V. Armstrong3, J. A. Brian4, S. E. Bryson5, N. Garon6, W. Roberts7, C. Roncadin8, L. Zwaigenbaum9 and I. M. Smith10, (1)Dalhousie University / IWK Health Centre, Halifax, NS, Canada, (2)McMaster University, Hamilton, ON, Canada, (3)IWK Health Centre / Dalhousie University, Halifax, NS, Canada, (4)Bloorview Research Institute, Toronto, ON, Canada, (5)Dalhousie University, Halifax, NS, Canada, (6)Mount Allison University, Sackville, NB, Canada, (7)University of Toronto, Toronto, ON, Canada, (8)Autism Spectrum Disorder Service, McMaster Children's Hospital - Hamilton Health Sciences, Hamilton, ON, CANADA, (9)Pediatrics, University of Alberta, Edmonton, AB, Canada, (10)Dalhousie University / IWK Health Centre, Halifax, NS, CANADA
Background: Siblings of children with autism spectrum disorder (ASD) show an increased risk (up to 18.7%) of developing the same disorder and an additional 28% rate of sub-clinical manifestations, developmental delays or deficits in other areas of development/behavior. However, the distinctive patterns by which the early symptomatology emerges in these children remain unclear.

Objectives: Here, we aim to define distinct developmental trajectories for ASD symptom severity for the total score and social affect (SA) and restricted/repetitive behaviors (RRB) subdomains of the Autism Diagnostic Observation Schedule (ADOS). Trajectory groups were examined from 1.5 years to 5-7 years of age. Early clinical and cognitive predictors (before 1.5 years of age) will also be determined for each measure

Methods: We used Group Based Trajectory Models (GBTM) to derive early symptom severity trajectory groups for three diagnostic measures: Total, SA and RRB scores from the ADOS at 18, 24, 36-42, and 60-84 months of age. The sample was composed of 502 high-risk siblings (281 males), of whom 128 received an ASD diagnosis at 36 months. Clinical and cognitive measures were also collected before this period (at 6, 12 and 18 months), with respectively the Autism Observational Scale for Infants (AOSI) and the Mullen Scales of Early Learning (MSEL). Predictors and diagnostic membership were examined according to the derived trajectory groups of symptom severity for each of the three diagnostic measures.

Results: Analysis revealed three distinct trajectory groups for the symptom severity Total score and two for each subdomain (SA and RRB). Pairwise comparisons between trajectory groups for quadratic slope estimates revealed significant differences for all comparisons (all p<.001). No significant difference in the intercepts was evidenced between trajectories for the Total score (all p>.24), but there were differences for the two subdomains (all p<0.01). As expected, children with an ASD diagnosis were more likely to be in the trajectory groups with the highest scores on Total, SA and RRB measures. Finally, from 6 months of age, language-related cognitive measures at the MSEL were more predictive of SA trajectory membership, and motor skills at RRB trajectory membership. From 12 months of age, AOSI clinical scores were also highly predictive of severity score trajectory membership for all three diagnostic measures.

Conclusions: Our results confirm substantial heterogeneity in the early emergence of ASD symptomology in children at high risk for ASD. The results also suggest that ADOS SA and RRB subdomain severity scores yield distinctive trajectories with distinctive predictors. The current study has clinical implication in revealing developmental heterogeneity in the early emergence of ASD symptomology in each diagnostic criterion domain.