27958
Symptoms of ASD in Children and Adolescents with a Diagnosed Mood or Anxiety Disorder
Poster Presentation
Saturday, May 12, 2018: 11:30 AM-1:30 PM
Hall Grote Zaal (de Doelen ICC Rotterdam)
A. Langmann1, I. Kamp-Becker2, S. Köhne3, L. Poustka4, S. Roepke5, V. Roessner6, N. Wolff7 and S. Stroth8, (1)Department of Child and Adolescent Psychiatry, , Psychosomatics and Psychotherapy, Medical Clinic, Philipps-University Marburg,, Marburg, IA, Germany, (2)Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps University Marburg, Schutzenstr 49, Germany, (3)Berlin School of Mind and Brain, Humboldt University Berlin, Berlin, Germany, (4)Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany, (5)Department of Psychiatry, Charite Berlin, Berlin, Germany, (6)Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden, Germany, (7)Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus Dresden, Dresden, Germany, (8)Philipps University Marburg, Marburg, Germany
Background: Autism spectrum disorders (ASD) and mood/anxiety disorders are commonly diagnosed in children and adolescents. Differentiation between the two is a diagnostic challenge, as there are several clinical symptoms that occur in both groups of disorders. Current studies suggest that symptoms such as early onset of symptoms, fear of changes, abnormal social interaction and communication as well as stereotyped, repetitive behaviour do occur in both groups of disorders. Furthermore, ASD and internalizing disorders can occur as comorbid conditions. The diagnostic gold standard for ASD comprises standardized behavioural assessment with the Autism Diagnostic Observation Schedule (ADOS-2), a specific interview (Autism Diagnostic Interview, ADI-R) and thorough differential diagnostic assessments.
Objectives: The explorative study investigated the diagnostic accuracy of ADOS-2 and ADI-R as well as possible symptom constellations that might facilitate differentiation of the two groups on the basis of the diagnostic measures.
Methods: A subsample of the ASD-Net consortium (www.ASD-Net.de), comprising data from n=792 individuals (age mean 11.6±5.1, IQ mean 95.9±19.4, 74% male; n=792 ASD, n=146 internalizing disorders, i.e. ICD-10 diagnoses F 32; F 40.1; F 93.2 and others) was explored with respect to sensitivity, specificity, ROC-analyses of the ADOS-2 and ADI-R results considering age, IQ and gender differences. Discriminant analyses were conducted to explore similarities/differences in reported and observed symptoms on domain and item levels.
Results: First analyses show sensitivities of 72–89% and specificities of 72–93% for the ADOS-2, with 4.0 - 27.8 % false positive diagnoses with the ADOS and up to 55.4 % false positive diagnoses with the ADI-R.
Conclusions: Due to high symptom overlap between the investigated disorders a thorough diagnostic assessment conducted by experienced clinicians is crucial.
