28027
Modeling Developmental Trajectories of White Matter Microstructure in the Autistic and Typical Brain

Poster Presentation
Friday, May 11, 2018: 11:30 AM-1:30 PM
Hall Grote Zaal (de Doelen ICC Rotterdam)
J. Villaruz1, D. C. Dean1, B. G. Travers1, A. Freeman1, M. B. Prigge2, B. A. Zielinski2, P. T. Fletcher2, J. S. Anderson3, E. Bigler4, N. Lange5, A. L. Alexander1 and J. E. Lainhart1, (1)University of Wisconsin - Madison, Madison, WI, (2)University of Utah, Salt Lake City, UT, (3)Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, (4)Brigham Young University, Provo, UT, (5)McLean Hospital, Cambridge, MA
Background: While neuroimaging studies have increasingly associated ASD with altered brain structure and connectivity, relatively little is understood about the development of the autistic brain. Longitudinal data to characterize the trajectories of white matter microstructure in both autism and a reference population, such as typically developing controls (TDC), may reveal which white matter tracts are most significantly influenced by ASD and provide a timeline for when such divergence occurs. A continuous and probabilistic model could give important insights into white matter development, but which growth models are most appropriate for its trajectory is unknown. Furthermore, it is uncertain whether the model that best characterizes ASD white matter development differs from that of typical development. Thus, studies examining growth models to determine which models provide the most accurate representation of white matter microstructure maturation are needed.

Objectives: Using diffusion tensor imaging (DTI) data from an ongoing longitudinal study of ASD, we investigated growth models of longitudinal white matter microstructure development and assessed which models best represent the developmental trajectories of 48 white matter tracts in individuals with ASD and TDC.

Methods: Male participants (N = 154; 99 ASD) between the ages of 3 and 52-years-old were scanned at the University of Utah up to 4 times across 9 years. The 48 white matter tracts defined in the JHU ICBM-DTI-81 template were aligned to a population-specific template created after image processing then median diffusion parameters were extracted for each tract. We fit the regional DTI data (i.e. FA, MD, RD, AD) to longitudinal linear and quadratic growth models and assessed which model best represented each tract’s development using the Bayesian Information Criterion parsimony metric. These best-fit models were compared between groups to examine whether white matter development in ASD and TDC follow different trajectories.

Results: The Bayesian Information Criterion revealed 80 instances across the 4-diffusion metrics (FA, MD, RD, AD) where the best-fit models differed between ASD and TDC. In particular, 18, 19, 19, and 24 of the 48 white matter tracts differed in their FA, MD, RD, and AD trajectories, respectively. In all but 3 of these cases, which included MD and RD in the fornix and AD in the left medial lemniscus, a linear growth model was found to better fit the TDC data while a quadratic model best fit the ASD population.

Conclusions: Quantitative analysis of white matter maturation may provide insight into processes that are altered during neurodevelopment in ASD. These preliminary findings suggest that the growth models used to represent the trajectory of white matter microstructure development differs between individuals with and without ASD. Notably, these differences appear to be regionally dependent as the trajectory differences were not observed in all investigated tracts. Further investigation into additional models, such as logistic or Gompertz growth models, is required to ascertain which model best characterizes the developmental trajectories of white matter. Future analyses will examine these additional models to assess whether they provide a more accurate representation of development and whether these models differ between ASD and TDC trajectories.