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Using the Boscc As Primary Outcome of the German A-FFIP Multicenter RCT

Poster Presentation
Friday, May 3, 2019: 5:30 PM-7:00 PM
Room: 710 (Palais des congres de Montreal)
J. Kitzerow1, S. Kleber2, Z. Kim3, K. Teufel3 and C. Freitag3, (1)Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and, Frankfurt am Main, Germany, (2)Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frakfurt am Main, Germany, (3)Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
Background: The Frankfurt Early Intervention Program for preschool children with ASD (A-FFIP)is a manualized low-intensive therapist-delivered and parent-supported early intervention program, which is currently studied for efficacy by a German multi-center randomized controlled trial (target sample N = 134 preschool-aged children at four study sites). The primary outcome measure is the Brief Observation of Social Communication Change(BOSCC). Several additional secondary outcome measures as well as mediating mechanisms are studied.

Objectives: To (1) present data on the feasibility to standardize the BOSCC assessment with an independent professional at the different study sites; (2) explore concordance of BOSCC (Version December 2017) results based on video-based coding of differently structured interaction scenes; (3) explore concurrent validity with the ADOS-2 based comparison score and ESCS based joint attention measures.

Methods: Cross-sectional data of N = 15 children, aged 2-5.5 years old are reported.

(1) Feasibility questionnaires were completed by all BOSCC-testers and descriptive data are reported. (2) The BOSCC coding system was applied to 4 different 12-minute video scenes: BOSCC, ADOS-2, DCMA, and ESCS. Mean scores were compared by rANOVA. (3) Pairwise correlation of BOSCC, ADOS-2, and ESCS derived measures was calculated.

Results: The BOSCC implementation was highly feasible; still, some errors had to be corrected during the training phase. BOSCC coding results did not differ by the structure of the scene or interaction. Similar to previous studies, medium correlations of BOSCC and ADOS-2 scores were replicated and medium to high correlations of BOSCC and different ESCS joint attention measures were found.

Conclusions: The BOSCC is a feasible and promising outcome measure to study change in core ASD symptoms in preschool aged children, which can be rated by blinded raters from different video scenes and also allows the re-coding of existing video-based material. The implementation of the BOSCC in several early intervention studies will allow a direct comparison of effect sizes between studies. The final analyses will include a larger sample.