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The CO-Occurrence of MRI Findings and Autism Spectrum Disorders:What Is the Importance of Pineal Cyst???
Objectives: Evaluate the simultaneous occurrence between magnetic resonance imaging findings, namely pineal cysts which shows a high prevalence in this group, and children diagnosed with autism spectrum disorders.
Methods: Retrospective case-control study carried out on 161 children: 93 cases diagnosed with autism spectrum disorder (38 with level 1 severity and 55 with level 2 severity) were compared with 68 controls (non-autistic patients). All participants had done a magnetic resonance image and were patients of the paediatric psychiatry appointments.
Results: This study shows that the prevalence of pineal cysts is higher in autistic children comparing with non-autistic children (84.6% vs 15.4%, p=0.041). If the level of severity of the autism is discriminated into level 1 and 2, there is also a significant difference between the groups (15.4% vs 84.6% vs 0.0% in non-autistic, level 1 and level 2 ASD, respectively, p<0.001). The latter association was analysed calculating the odds of the presence of pineal cyst and having level 1 autism which was increased but with a wide variability (OR, 95%CI 13.75, [2.38 – 79.38]).
Conclusions: There is a possible association between pineal cysts and autism spectrum disorders as shown in this study. This association is stronger in the children diagnosed with level 1 autism, since it is the group with the highest prevalence of pineal cysts (11.8%). It would be interesting to further explore the factors underlying this correlation by extending the study to a larger sample.