The Circadian Timekeeping System As a Window into Neurodevelopmental Disorders
There is an abundance of evidence from both the clinic and animal models that suggests a strong interplay between circadian rhythms and ASDs, however the mechanisms remain an area of active inquiry. I will review the molecular and cellular biology of the circadian clock and its links to animal and clinical models of ASD. I will review how the biology underlying syndromic disorders related to ASD such as Tuberous Sclerosis Complex, Fragile X Syndrome, and Angelman’s syndrome is intimately intertwined with circadian biology. I will suggest that many ASDs (and related disorders) are, at a fundamental level, ‘rhythm-opathies’.
The nexus between circadian clocks, sleep, and ASD is a new and important frontier that will lead to new targets and new therapies.
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