EEG in Cognitive Tasks in Preclinical Models As Translational Biomarker
Methods: Humans were tested in a variety of behavioral paradigms including the probabilistic learning task (PLT) progressive ratio breakpoint task (PRBT), and 5-choice continuous performance task (5C-CPT), while neural electroencephalogram (EEG) recording was conducted. Similarly, C57BL/6J mice performed touch-screen analogs of these paradigms while or dura-resting EEG-like signal was recorded for direct comparable analysis.
Results: During PLT performance we observed that frontal Reward Positivity scaled with the degree of positive prediction error, varying in strength according to probability ratio in both humans and mice. On the PRBT we observed parietal alpha power was elevated as both humans and mice neared their breakpoint. In the 5C-CPT, performance varied based on task difficulty in both humans and mice and post response EEG stimuli exhibit consistencies across species.
Discussion: We demonstrated the capability of utilizing identical methods for investigating rodent neuronal activity performing the same behavioral tasks available in rats and humans, in cognitive control, effortful motivation, and reward learning. Current studies will determine whether psychopharmacological challenges alter EEG signaling consistently across humans and rodents. These techniques provide important information regarding the validity rodent models to neural circuitry of behaviors relevant to psychiatry in addition to the likelihood of translating drug-induced changes in performance across species.
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