Health and well-being are considered core domains of quality of life (QOL) in autism research and are synergistic with other QOL domains and transition success. For example, greater vocational independence and engagement have been related to subsequent reductions in maladaptive behaviors. Self-determination, which encompasses identifying one's wants and needs, problem-solving obstacles, advocating for one’s self, and believing that one has the capability to make positive changes for one’s own life path, provides an essential foundation for other core domains of QOL. Research focused on health and well-being in transition-age youth and adults with autism spectrum disorder (ASD) has lagged far behind other types of ASD-related research. With many individuals with ASD turning 18 years old (estimated at 500,000 over the next decade), broadening our understanding of health and well-being, while improving QOL, in this population is timely and relevant. This panel will focus on topics related to health in transition-age youth and adults with ASD including the barriers and facilitators of a smooth transition from pediatric to adult care, sex differences in physical health conditions and healthcare utilization, predictors of self-determination, and the associations of self-determination and autism identity with physical and psychological health and QOL.