Research and clinical care for non-syndromic and syndromic ASD have been hampered by limitations in access of families to research and medical centers. Intervention programs require creativity and flexibility in design and implementation to maximize scalability. In this symposium, we present four innovative models of remote clinical care and/or intervention delivery for children with autism and related neurodevelopmental disorders (NDDs). We begin with a presentation by Drs. Connie Kasari and Stephanie Shire which describes the effectiveness of three community partnered effectiveness-implementation hybrid trials of JASPER (Joint Attention, Symbolic Play, Engagement, and Regulation). Next, Dr. Alexander Kolevzon introduces the new ECHO model of clinical care delivery for Phelan McDermid Syndrome (PMS), through the PMS Neuropsychiatric Consultation Group (PMS-NCG). Dr. Hedda Meadan then discusses the Internet-Based Parent-implemented Communication Strategies (i-PiCS) program, which uses telepractice to coach parents in strategies to promote social-communication skills in their children. Finally, Elizabeth Berry-Kravis presents her NeuroNext NN107 trial which will evaluate effects of a pharmacological intervention on language learning from a remotely delivered parent-implemented language intervention in children with Fragile X syndrome. Lessons learned and strategies developed from these innovative studies can greatly inform the development of more scalable models of intervention delivery across NDDs.