• Background
  • Generation of Tbr1 A136PfsX80 mouse line
  • Tbr1 A136Pfs is a loss-of-function mutation
  • Tbr1 LOF does not affect growth or motor development
  • A136Pfs mice phenocopy Tbr1-null cortical development
  • Tbr1 LOF causes abnormal axon development
  • A136Pfs mice show altered interneuron distributions
  • Future Directions, Reference, & Funding