27843
Exploring Theory-of-Mind in Children, Adolescents and Adults with Autism Spectrum Conditions in a Large European Cohort

Poster Presentation
Friday, May 11, 2018: 5:30 PM-7:00 PM
Hall Grote Zaal (de Doelen ICC Rotterdam)
H. L. Hayward1, K. L. Ashwood2, F. Happé3, R. Holt4, S. Baron-Cohen5, E. Loth6, M. C. Lai7, D. V. Crawley6, D. G. Murphy8, A. San Jose Caceres6 and J. Ahmad6, (1)Institute of Psychiatry, Psychology and Neuroscience, King’s College London, King's College London, London, United Kingdom, (2)Department of Forensic and Neurodevelopmental Sciences, and the Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom, (3)Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, (4)University of Cambridge, Cambridge, United Kingdom, (5)Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, (6)Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom, (7)Centre for Addiction & Mental Health, University of Toronto, Toronto, ON, Canada, (8)Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
Background:

‘Theory of Mind’ (ToM) hypothesis is a prominent account of social-communicative impairments in ASC; the ability to ascribe mental states to others/self to predict behaviours (Baron-Cohen, et al., 2000). Studies report many adolescents/adults with ASC pass ‘first-order’ tasks, yet struggle in social situations (Klin, 2000). This has led to the distinction between ‘first order’ ToM abilities (e.g. ‘false belief’ measured in a continuous manner by the “Sandbox” task (Begeer et al., 2012)), and perhaps more pervasive impairments in spontaneous usage (Klin, 2000; Volkmar et al., 2004). One paradigm that taps spontaneous attribution of mental status is the ‘animated shapes’ task that elicits a (verbal)ToM response more akin to the “social demands” inherent in real-life.

Objectives:

To investigate false belief and spontaneous ToM usage in a mixed sex cohort of males and females with ASD across different ages and IQ. Associations between ToM and social-communicative abilities will also be examined

Methods:

Participants with ASCs (N=363) and age-matched typically developing (TD) participants (N=262) recruited as part of EU-AIMS Longitudinal European Autism Project (LEAP). A battery of cognitive tasks included the Frith-Happe Triangles animations ‘Animated Shapes’ task (Abell et al 2000; Castelli et al., 2002) and the continuous false belief ‘Sandbox’ task to assess theory of mind. The ‘Triangles’ task were audio-recorded/transcribed/analysed for “accuracy” (I.e. correct inference of underlying scenarios) and “psychological state descriptions” (i.e. use of mental state terms) using a scoring system developed by the authors, based on Castelli (2000). 100% of the narratives were scored by two raters at each LEAP site, inter-rater reliability was above 91% across.

IQ assessed using the WASI, autism symptomatology using the (parent-report) Social Responsiveness Scale (SRS-2), adaptive functioning using the Vineland (VABS-III).

2 (group) x 2(sex) x 3 (age group: child, adolescent, adult) between-subject ANOVAs were used.

Results:

Both tasks revealed moderate correlations in both groups (ASC: r =.25, p = .01;TD: r =.14, p = .05).

The “Sandbox” task found a significant effect of group (F(1,516)=8.403, p<.05, d= 0.24) with the ASC group performing significantly worse (i.e. greater egocentric bias) than TDs.

No group differences found on the ‘Triangles’ task. Significant effect of sex(F(1,609)=6.938, p<.05, d=0.28)(females<males) and age(F(3,609)=33.349, p<.001)(children<adolescents<adults) found, effects do not hold with diagnosis.

The ‘triangles’ task was moderately correlated with ASD symptomatology in both groups (TD; r =-.31, p < .01, ASC; r =-.21, p < .01). ‘Sandbox’ task correlated with ASC symptomatology in the ASC group only(r =-.16, p < .01).

In the ASC group, the ‘triangles’ task was correlated with adaptive behaviour (r =-.14, p = .05) in males, and adolescents (social domain, r =-.23, p = .05). TD group; the ‘triangles’ task correlated with Communication(r =-.20, p = .05).

The continuous FB task correlated with adaptive behaviour in the ASC group, (daily living(r =.22, p = .01.;communication(r=.15, p=.05 );social(r=.30, p=.01)) in males. In the TD males, it correlated with all domains of adaptive behaviour.

Conclusions: We report group differences in prompted ToM usage, though find no group deficits in spontaneous ToM usage in individuals with ASC.